Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-B signaling
Identifieur interne : 000442 ( Main/Exploration ); précédent : 000441; suivant : 000443Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-B signaling
Auteurs : Di Sha [États-Unis] ; Lih-Shen Chin [États-Unis] ; Lian Li [États-Unis]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2010-01-15.
Abstract
Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson disease (PD), but how these mutations trigger neurodegeneration is poorly understood and the exact functional relationship between PINK1 and parkin remains unclear. Here, we report that PINK1 regulates the E3 ubiquitin-protein ligase function of parkin through direct phosphorylation. We find that phosphorylation of parkin by PINK1 activates parkin E3 ligase function for catalyzing K63-linked polyubiquitination and enhances parkin-mediated ubiquitin signaling through the IB kinase/nuclear factor B (NF-B) pathway. Furthermore, the ability of PINK1 to promote parkin phosphorylation and activate parkin-mediated ubiquitin signaling is impaired by PD-linked pathogenic PINK1 mutations. Our findings support a direct link between PINK1-mediated phosphorylation and parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-B neuroprotective signaling pathway in the pathogenesis of PD.
Url:
DOI: 10.1093/hmg/ddp501
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